Pipeline
AVN944 References
Talks
J. Strovel, et. al. “Gene expression biomarkers for AVN944 activity are conserved from in vitro cell lines to ex vivo treated primary leukemia patient samples, and can be used to monitor drug induced IMPDH inhibitors.” Clinical Ligand Assay Society Meeting, May 2006. Louisville, KY


Posters
Jeffery W. Strovel, Tammy Lawrence, Marion Chakiath, Pachai Natarajan, Karina Zuck, Stephen Glanowski and David K. Bol “Modulation of Gene Expression and Guanosine Pools by Inhibition of Inosine Monophosphate Dehydrogenase (IMPDH); correlating In Vitro Cell Resistance with Biomarker Response in Patient Samples from the Phase I Trial” (pdf) AACR Annual Meeting , April 14-18, 2007, Los Angeles, CA

Zoe Weaver, Jeffery W. Strovel, Marion Chakiath, Pachai Natarajan, Tammy Lawrence, and David K. Bol “Antiangiogenic Properties of AVN944, A Potent Inhibitor of IMPDH” (pdf) AACR Annual Meeting , April 14-18, 2007, in Los Angeles, CA

Jeffrey W. Strovel1, Marion Chakiath1, Stephen Glanowski1, Anna Glodek1, Simon Katz1, Tammy Lawrence1, Pachai Natarajan1, Karina Zuck1, Lenore Urbani2, Beverly Mitchell2, and David K. Bol1. 1Avalon Pharmaceuticals, Germantown, MD; 2Stanford Comprehensive Cancer Center, Stanford, CA. “Genetic and biochemical biomarkers of IMPDH inhibition in phase I dose escalation of AVN944 for hematologic malignancies”. American Association of Hematology Annual Meeting, Orlando, FL, Dec 2006.

D.K. Bol, J. Strovel, M. Douvas, P. Natarajan, Q. Zong, J. Castaneda, M. Chakiath, and B. Mitchell. “Genetic response markers for IMPDH inhibition are conserved from in vitro cell lines to ex vivo treated primary samples from leukemia patients.” (pdf) AACR Annual Meeting. Experimental and Molecular Therapeutics #3124. Washington, D.C., April 4, 2006.

J. Strovel, J. Jain, P. Natarajan, T. Lawrence, J. Castaneda, M. Chakiath, K. Zuck, M.W. Harding, K. Kelliher, B. Shames, R. Ramachandran, M.C. Botfield, D.K. Bol. “Global gene expression effects of AVN-944, a novel small molecule inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH).” (pdf) AACR Annual Meeting. Proc. Am. Assoc. Cancer Res. 47 (#3125) p.736, Washington, D.C., April 4, 2006.